Acta Biol Hung 51:343-348. Here we genetically remove dendrites in Drosophila motoneurons, followed by analysis of functional outcomes. J Neurophysiol 100(5):2525-36. Ryglewski S, Duch C (2009) Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron. The University of Mainz (full name Johannes Gutenberg University Mainz) (German: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. Wären Kameras an besonders betroffenen Stellen … PNAS 111(50):18049-54. Int Comp Biol 46:E36. When analyzing the role of dendrites, the experimental challenge is to abolish them selectively in identified Drosophila wing motoneurons without affecting other properties of these specific neurons or others. Exkursion LL BiMA. Hutchinson K, Vonhoff F, Duch C (2014) Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons. Find more data about mail. Ryglewski S, Kadas S, Hutchinson K, Schuetzler N, Vonhoff F, Duch C (2014) Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. Duch's work group at Mainz University is investigating dendritic structures and functions using the fruit fly Drosophila as a model organism. Kühn C, Duch C (2013) Putative Excitatory and Putative Inhibitory Inputs Localize to Different Dendritic Domains in a Drosophila Flight Motoneuron. Raum 01-230 (Gebäude Recht und Wirtschaft I) Tel. Dev Biol 297(1):214-227. links to network IP address J Neurosci 27(41):11122-31. Page-Name:IDN Homepage Last Update:12.October 2017 J Comp Neurol 403:119-134. PLoS One, 7(2):e31835. Lukas Kilo, Ph.D. Student, PNAS 116(9):3805-3810. Fax +49 6131 39-25548. Morris OT, Duch C, Stevenson PA (1999) Reflex activation of locust octopaminergic modulatory neurons by proprioreceptors responsive to flight muscle contractions. Duch C (2006) Form and function of identified insect motoneurons. Corresponding Author. Mainz [1] [2] [3] ou Mogúncia [4] [5] (em alemão: Mainz, em latim: Mogontiacum, em francês: Mayence) é uma cidade da Alemanha, capital do estado federal de Renânia-Palatinado. Please note: Due to the amount of requests reaching the “Studierendenservice” at the moment there is a delay up to one week in answering them. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany Proceedings of the National Academy of … (3)Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany; Neurons are the building blocks of the brain. However, the mechanisms and cellular targets of TA modulation of locomotor activity are incompletely understood. OA generally enhances locomotor behaviors such as Drosophila larval crawling and flight, whereas TA decreases locomotor activity. • determine the functional consequences of correct and false regulation of neuronal properties for synaptic integration, neuronal firing patterns, and behavior in the healthy and in the diseased brain. Consoulas C, Duch C, Bayline RJ, Levine RB (2000) Behavioral transformations during metamorphosis: remodeling of neural and motor systems. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. Neurons are the building blocks of the brain. DEGREE COURSE: Guide to the Bachelors and Masters Degree Programs J Neurosci 24:9826-9837. Börner J , Puschmann T, Duch C (2006) A steroid hormone affects sodium channel expression in Manduca central neurons. Libersat F, Duch C (2004) Cellular and molecular mechanisms of the maturation of neuronal dendritic trees. J Neurophysiol 102:41-58. Duch C, Pflueger HJ (1995) Motor patterns for horizontal and upside down walking and vertical climbing in the locust. Kadas D, Ryglewski S, Duch C (2015) Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion. Eur J Neurosci 23:335-349. The biogenic amines octopamine (OA) and tyramine (TA) modulate insect motor behavior in an antagonistic manner. J Comp Neurol, 518:2169-2185. Advising by appointment only. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. Duch C, Levine RB (2002) Changes of calcium signaling during postembryonic dendritic growth in Manduca sexta. Inst. J Neurosci 15:1109-1113. Burg Lahneck. Therefore, even with a complete connectome in hand, understanding brain function requires an intricate analysis of the physiology and functional morphology of its component neurons. J Neurophysiol 93:2331-2342. J Neurophysiol 87:1415-1425. Stocker B, Bochow C, Damrau C, Mathejczyk T, Wolfenberg H, Colomb J, Weber C, Ramesh N, Duch C, Biserova NM, Sigrist S, Pflüger HJ. Dutta S, Rieche F, Eckl N, Duch C, Kretzschmar D (2015) Glial expression of Swiss-Cheese, the Drosophila orthologue of Neuropathy Target Esterase, is required for neuronal ensheathment and function. eNeuro. Pflueger HJ, Duch C, Heidel E (2004) Neuromodulatory octopaminergic neurons and their functions during insect motor behaviour. Ryglewski S, Vonhoff F, Scheckel K, Duch C (2017) Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.352 55128 Mainz Tel: +49 6131/3923419 Fax: +49 6131/3925443 e-mail: Vonhoff F, Kühn C, Blumenstock S°, Sanyal S, Duch C (2013) A precise temporal coherency between receptor expression, neural activity, and AP-1 dependent transcription regulates dendrite development in an identified Drosophila motoneuron. Mar 19;12:5. doi: 10.3389/fnsys.2018.00005. J Comp Neurol, 518:2437-2455. Additional information about this page. Unravel Resilience - Using Multi-Omics Integration to explore the Molecular Background of Stress Resilience Resilience is the ability to cope with stress or to quickly recover to pre-crisis state after being exposed to extreme stress. 2. Mol Neurobiol 29:303-320. Kathryn Scheckel, Carsten Duch Correspondence In Brief Ryglewski et al. Biogenic amines, like norepinephrine, can act as neuromodulators to render animal behavior adaptive to changing external and internal conditions. J Comp Physiol A 184:489-499. (2)Institute of Molecular Biology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany. 9.00-12.00) Tel. Close affiliations . Look up the English to German translation of uni Mainz in the PONS online dictionary. Email: Search for more papers by this author Perturbations cause dendrite shifts and result in defects of adaptive motor control. The promotion and introduction of new ideas, the use of knowledge to improve people’s lives and encourage them to overcome the many boundaries they encounter daily – these are the underlying ambitions of Johannes Gutenberg University Mainz. Vonhoff F, Williams A, Ryglewski S, Duch C (2012) Drosophila as a Model for MeCP2 Gain of Function in Neurons. E-Mail: joerg.korff@uni-mainz… uses Microsoft HTTPAPI web technologies. J Neurophysiol 102(6):3673-88. Duch C, Vonhoff F, Ryglewski S (2008) Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability. Pathobiochem., UM Mainz: Carsten Duch Inst. Eur J Neurosci, 37(6):860-75. Development 140(3):606-16. Aging (Albany NY). Institute of Neurobiology, Johannes Gutenberg University of Mainz, Mainz, Germany. Disease Models & Mechanisms, Dec 3 [Epub ahead of print]. Neurobiol of Disease, in press. Adrenergic signaling profoundly modulates animal behavior. J Physiol 593(22):4871-88. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and membrane currents. Duch C, Mentel T, Pflueger HJ (1999) Distribution and activation of different types of octopaminergic DUM neurons in the locust. Mit Erfahrungsberichten, NC-Liste und zulassungsfreien Studiengängen. Williams AA, White R, Sniard A, Corneveaux J, Huentelman M, Duch C (2016) MECP2 impairs neuronal structure by regulating KIBRA. Somos uma instituição de Educação que atua nas áreas de Treinamento em Desenvolvimento Profissional e Gerencial desde fevereiro de 2003. We use the versatile genetic model system Drosophila melanogaster for our research. Fields L, Duch C, Pflueger HJ (2007) Reflex activation of octopaminergic unpaired median neurons in the locust. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. (2018) Structural and Molecular Properties of Insect Type II Motor Axon Terminals. Group (open) – Master Erziehungswissenschaft, Uni Mainz. Duch C, Mentel T (2003) Motoneuron terminal retraction and outgrowth depend on stage-specific activity patterns during the metamorphosis of Manduca sexta. J Comp Physiol 195(5):473-89. Meseke M, Evers JF, Duch C (2009) Postembryonic dendritic remodeling of an identified neuron is accompanied by changes in synapse distribution and dendritic input computation. Ryglewski S, Duch C, Altenhein B (2017) Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase. J Comp Neurol 422:1-17. Background: To compare the efficacy and safety of timolol 0.5% versus brinzolamide 1.0% when added to travoprost monotherapy in patients with primary open-angle glaucoma or ocular hypertension. Bayline RJ, Duch C, Levine RB (2001) Nerve-muscle interactions regulate motor terminal growth and myoblast distribution during muscle development. Cell Tissue Res 334:477-498. Pflueger HJ, Duch C (2011) Dynamic neural control of insect muscle metabolism related to motor behavior. Vierk R, Pflueger HJ, Duch C (2010) Postembryonic development of centrally generated flight motor patterns in the hawkmoth, Manduca sexta. To understand the adaptive regulation of these properties our research objectives are: • identify the molecular mechanisms that regulate electrical and morphological properties of neurons. E-mail: Fone: 0800.005.3005 Escritório em São Paulo - SP: Av. Duch, Univ.-Prof. Dr. Carsten Address: Hanns-Dieter-Hüsch-Weg 15,55128 Mainz Building: BioZentrum I (1578) Room: 02-352 Phone: +49 6131 39 23419 - Fr. Arbeitsgruppe/Research team Prof. Dr. C. Duch. J Exp Biol 198:1963-1976. Each neuron must acquire a specific ‘Gestalt’ and a defined set of ion channels during development and maintain them within critical ranges throughout life. The Ernst Florey memory lecture. J Neurosci 37(45):10971-10982. Cell Biology, JGU Mainz: Albrecht Clement Inst. Vonhoff F, Duch C (2010) Tiling Among Stereotyped Dendritic Branches in an Identified Drosophila Motoneuron. Baudoux S, Duch C, Morris OT (1998) Coupling of efferent neuromodulatory neurons to rhythmical leg motor activity in the locust. Evers JF, Muench D, Duch C (2006) Developmental relocation of presynaptic terminals along distinct types of dendritic filopodia. Libersat F, Duch C (2002) Morphometric analysis of dendritic remodeling in an identified motoneuron during postembryonic development. Börner J, Duch C (2010) A standard neuroanatomy atlas for the adult Drosophila ventral nerve cord. Duch C 2 Affiliations . Current project. Synapses determine information processing between neurons, whereas electrical properties as well as structure determine information processing within neurons. J Neurosci 20:6950-6961. Die rechteckige Kernburg ist von vier Gebäudeflügeln und einer Schildmauer mit Ecktürmen umgeben. Ryglewski S, Pflueger HJ, Duch C (2007) Expanding the Neuron’s Calcium Signaling Repertoire: Intracellular Calcium Release via Voltage induced PLC and IP3R Activation. 55099 Mainz Germany. J Comp Neurol 450:153-166. doi: 10.1523/ENEURO.0181-19.2019. Schützler N, Girwert C, Hügli I, Mohana G, Roignant JY, Ryglewski S*, Duch C* (2019) Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state. University Medical Center Mainz | 2,450 followers on LinkedIn. J Comp Physiol A: 196(1):37-50. Mol. Herrera-Valdez MA, McKiernan EC*, Berger SD*, Ryglewski S, Duch C, Crook S (2013) Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. Stefanie Ryglewski, Ph.D., Duch C, Bayline RJ, Levine RB (2000) Development of the DLM flight motor system in Manduca sexta. Pflueger HJ, Duch C (2000) The functional role for octopaminergic neurons in insect motor behavior. Die Entfernung von Graffiti kostet die Johannes Gutenberg-Universität jährlich rund 80.000 Euro. eBook - JaSeAn. Neuroimage 23:1283-1298. Meseke M, Evers JF, Duch C (2009) PTX-induced hyperexcitability affects dendritic shape and GABAergic synapse density but not synapse distribution during Manduca postembryonic motoneuron development. Kuehn C, Duch C (2008) Expression of two different isoforms of fasciclin II during postembryonic central nervous system remodeling in Manduca sexta. Group (closed) – BA Erziehungswissenschaften, Uni Mainz. ℹ️ receives about 38,037 unique visitors per day, and it is ranked 25,698 in the world. Brain Res Bulletin 53:571-583. : +49 (0) 6131 / 39 - 21979 Fax: +49 (0) 6131 / 39 - 23 004. Ryglewski S, Kilo L, Duch C (2014) Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron Eur J Neurosci, 39(10):1572-85. Approximately 100 billion neurons in our brain form 100 trillion synapses onto 100,000 miles of dendritic cable. Duch C, Pflueger HJ (1999) DUM neurons in locust flight: a model system for amine mediated peripheral adjustments to a central motor program. Besucheranschrift / Office: Hanns-Dieter-Hüsch-Weg 15 (Gebäude 1578, 2.Stock, 02-352) 55128 Mainz Duch C, Levine RB (2000) Remodeling of membrane properties and dendritic architecture accompany the postembryonic conversion of a ‘slow’ into a ‘fast’ motoneuron. J Comp Physiol A: 195(3):265-77. Hotline +49 6131 39-22122. J Insect Physiol 54(1):240-54. In addition to the unprecedented genetic tools available in Drosophila, the transformation from the larval to the adult stage during metamorphosis is a striking example of postembryonic nervous system plasticity and remodeling, and the functions of individually identified neurons can directly be related to stage specific behaviors. Physiology (Bethesda) 26:293-303. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.356 D 55128 Mainz Mo. 1. Ryglewski S, Lance K, Levine RB, Duch C (2012) Cav2 Channels Mediate LVA and HVA Calcium Currents in Drosophila Motoneurons. Uni Mainz. Mainz é uma cidade independente ( kreisfreie Stadt ) ou distrito urbano ( Stadtkreis ), ou seja, possui estatuto de distrito ( … Brembs B, Christiansen F, Pflueger HJ, Duch C (2007) Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. Includes free vocabulary trainer, verb tables and pronunciation function. We are interested in the functional diversity of voltage gated calcium channels and its implications for normal neurophysiology ans behavior. Nove de Julho, 5229 - 5° Andar Homepage. report that competitive mechanisms are required to correctly partition synaptic inputs from different transmitter systems on the dendritic arbor of a Drosophila motoneuron. 11(6):1850-1873. doi: 10.18632/aging.101880. Vierk R, Pflueger HJ, Duch C (2009) Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. eNeuro. With approximately 32,000 students (2018) in about 100 schools and clinics, it is among the largest universities in Germany. Evers JF, Schmitt S, Scholz M, Duch C (2005) New frontiers in functional neuroanatomy: precise automatic reconstruction from confocal image stacks. J Exp Biol 202:3555-3564., European J Neurosci 17:1-18. Mainz, Renânia-Palatinado, Alemanha: Presidente Georg Krausch Total de estudantes: 37 039 Página oficial website oficial: A Universidade Johannes Gutenberg de Mainz (em alemão: Johannes Gutenberg-Universität Mainz) é uma instituição de ensino superior localizada em Mainz, no estado da Renânia-Palatinado, Alemanha. Mentel T, Duch C, Müller U, Stypa H, Wegener G, Pflueger HJ (2003) Fuel selection in locust flight muscle by the activity of central modulatory neurons. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and … E-Mail. Ryglewski S, Duch C (2012) Preparation of Drosophila Central Neurons for in situ Patch Clamping. J Neurosci 34(5):1924-31. Prof. Dr. Carsten Duch. Die spätstaufische Burg der Erzbischöfe und Kurfürsten von Mainz wurde um das Jahr 1245 zum Schutz des Gebiets an der Lahnmündung erbaut. Toplinks. eCollection 2018. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. Group leader. Schmitt S, Evers JF, Scholz M, Duch C, Obermayer K (2004) New methods for the computer assisted 3D reconstruction of neurons from confocal image stacks. Methods: Patients meeting selection criteria (IOP one eye 19 mmHg and ≤32 mmHg and IOP both eyes ≤32 mmHg at 8:00 h) were switched to travoprost monotherapy for 4 weeks. J Physiol J Physiol 590(Pt 4):809-25. and the secretary: Renate Bertgen. To address these questions we use Drosophila melanogaster as a model system. Duch C, Mentel T (2004) Activity affects dendritic shape and synapse elimination during steroid induced dendritic regression in Manduca sexta. Accordingly, dendritic defects are consistent anatomical correlates of numerous brain diseases, but specific causality remains unproven. Dev Biol 231:348-363. J Neurophysiol 79:361-370. Johannes Gutenberg-Universität Mainz Jakob-Welder-Weg 9 55099 Mainz. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Front Syst Neurosci 11:68, Kadas D, Klein A, Krick N, Worrell JW, Ryglewski S, Duch C (2017) Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. Cell Tissue Res 325:175-87. Arbeitsgruppe von der Theorie zur Forschungspraxis. Johannes Gutenberg University Mainz was originally founded in 1477 and today still strives to emulate the innovational spirit of its namesake. Neuron 93(3):632-645.e6. PLoS Biol 5(4):e66. J Comput Neurosci 34(2):211-29. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. J Vis Exp 15;(68). J Neurosci Methods 15:168(1):64-70. doi: 10.1523/ENEURO.0181-19.2019. Hohensee S, Bleiss W, Duch C (2008) Correlative electron and confocal microscopy assessment of synapse localization in the central nervous system of an insect. * Shared last author. However, in a computing, adapting, and learning system such as the brain, these properties must also retain functional plasticity. Acta Biol Hung 55:3-12. 1990-1994 Study of Biology, Free University Berlin 1994 Diploma of Biology, Free University Berlin 1995-1998 PhD Student at the Institute of Neurobiology, Free University Berlin Front Syst Neurosci. Physiology, UM Mainz: Amparo Acker-Palmer Cell Biology, GU Frankfurt: Eva-Maria Albers Dept. Group (private) – Master of Education, Uni Mainz. Alles zur Johannes-Gutenberg-Universität Mainz und ihren 204 Studiengängen. Corresponding author C. Duch: Institute of Neurobiology, Johannes Gutenberg University of Mainz, Col.‐ Kleinmann Weg 2, 55099 Mainz, Germany. Burkert P, Duch C (2006) Developmental changes of CaMKII localization, activity and function during postembryonic CNS remodeling in Manduca sexta.

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